Table 2.
Morphometric analysis of liver tissue in healthy mice and mice with RLS40 after the treatment under Scheme 2.
| PCHT courses, number | Days after treatment | Hepatocyte degeneration, Vv, % (Mean ± SEM) | Hepatocyte necrosis, Vv, % (Mean ± SEM) | Volume density of hepatic lymphoma infiltration, Vv, % | ||
|---|---|---|---|---|---|---|
| Healthy mice | Mice with RLS40 | Healthy mice | Mice with RLS40 | |||
| (n = 45) | (n = 45) | (n = 45) | (n = 45) | |||
| Baseline# | 7.3 ± 0.7 | 12.6 ± 1* | 3.1 ± 0.5 | 12.1 ± 1* | — | |
|
| ||||||
| 1 | 1 | 33.7 ± 2.2 | 40.7 ± 3.2 | 17.1 ± 1.1 | 13.5 ± 1.2* | — |
| 3 | 24 ± 2.1 | 20.6 ± 1.6 | 16.4 ± 1.4 | 19.2 ± 1.3 | — | |
| 7 | 15.7 ± 0.9 | 27.7 ± 1.6* | 12.6 ± 1 | 18 ± 1.35* | 15 ± 4 | |
|
| ||||||
| 2 | 1 | 27.5 ± 1.5 | 25.9 ± 1.2 | 19.7 ± 1.7 | 24 ± 1* | — |
| 3 | 26.6 ± 1.7 | 40.7 ± 2.1* | 17.6 ± 1.4 | 20.8 ± 1.3 | — | |
| 7 | 31.4 ± 1.8 | 29.6 ± 1.9 | 17 ± 1 | 37.9 ± 3.7* | 26 ± 4 | |
|
| ||||||
| 3 | 1 | 27.2 ± 1.2 | 34.3 ± 3* | 13.6 ± 1.3 | 40.8 ± 3.6* | — |
| 3 | 27.9 ± 1.3 | 36.9 ± 2.6* | 9.6 ± 0.9 | 47.7 ± 4.1* | 30 ± 5 | |
| 7 | 28.7 ± 1.2 | — | 22.9 ± 1.2 | — | — | |
*P ≤ 0.05 compared to healthy mice.
#Initial level determined just before treatment (6th day after tumor transplantation).