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. Author manuscript; available in PMC: 2012 Dec 9.
Published in final edited form as: Am J Transplant. 2009 Sep 25;9(12):2679–2696. doi: 10.1111/j.1600-6143.2009.02831.x

Figure 1.

Figure 1

Normal human myocardium; H&E section shows normal histology (a) with negligible TUNEL staining in a few CM (open arrow) and in CD31-positive VEC (arrow) (b). A marked co-expression for TNFR1 and ASK1Ser967 is seen in (open arrows), in resident MNC and in VEC (inset; arrowheads) (c,d). Co-expression of TNFR1 and ASK1pThr845 is seen in resident MNC (arrowheads) (e,f). TNFR2 and activation of Etkp is demonstrated in VEC (arrows) and Etkp is also detected in a few CM (open arrow) (g,h). TNF is confined to microvessels (arrows) and in MNC (arrowhead) and TACE is present in CM (open arrow) (I,j). TNFR1 mRNA is present in CM (open arrow) and in VEC (arrows) (k) while mRNA for TNFR2 and TNF is confined to VEC (arrows) and in MNC (arrowheads) (l,m). Dotted lines mark out the vessels. Images are representative of 10 different samples, each of which gave similar results. Cardiomyocytes (CM); Vascular endothelial cells (VEC); Mononuclear cells (MNC). (Original Mags: a, ×112; b; ×63; c–d; ×40; e–f; ×63; g–I; ×40; j; ×63; k–m, ×235).