Table 2. Trends in Survival and Neurological Outcomes.
Risk-adjusted rates of survival to discharge, acute resuscitation survival, post-resuscitation survival, and neurological disability for each calendar year are reported for the overall cohort. Rates are adjusted for temporal changes in patient and hospital characteristics [see eTable 3 for all model covariates].
| Risk-Adjusted Rates* | Adjusted RR per 1-year** (95% CI) | P for Trend** | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 2000 | 2001 | 2002 | 2003 | 2004 | 2005 | 2006 | 2007 | 2008 | 2009 | |||
| OVERALL | ||||||||||||
| Survival to Discharge, % | 13.7 | 17.1 | 18.2 | 17.8 | 18.9 | 20.0 | 20.5 | 21.2 | 23.3 | 22.3 | 1.04 (1.03, 1.06) | <0.001 |
| Acute Resuscitation Survival†, % | 42.7 | 45.1 | 45.4 | 46.0 | 47.0 | 48.6 | 49.7 | 52.5 | 55.2 | 54.1 | 1.03 (1.02, 1.04) | <0.001 |
| Post-Resuscitation Survival‡, % | 32.0 | 38.3 | 40.0 | 39.0 | 40.8 | 42.1 | 42.4 | 41.5 | 43.6 | 42.9 | 1.02 (1.01, 1.03) | 0.001 |
| Neurological Outcome in Survivors, % | ||||||||||||
| Significant Disability# (CPC > 1), % | 32.9 | 35.7 | 31.9 | 34.3 | 34.0 | 33.1 | 33.0 | 32.7 | 31.8 | 28.1 | 0.98 (0.97, 1.00) | 0.02 |
| Severe Disability¶ (CPC > 2), % | 10.1 | 10.5 | 9.8 | 10.5 | 11.5 | 11.5 | 9.7 | 12.2 | 11.7 | 10.7 | 1.01 (0.98, 1.04) | 0.37 |
Abbreviations: CI, confidence interval; CPC, cerebral performance category; RR, rate-ratio.
Risk-adjusted rates for each calendar year were obtained by multiplying the observed rate for the reference year (2000) by the corresponding rate-ratios for 2001 through 2009 from a model evaluating calendar year as a categorical variable
Determined from a model evaluating calendar year as a continuous variable
Acute Resuscitation Survival was determined by the number of patients with return of spontaneous circulation for at least 20 minutes divided by the number of patients with a cardiac arrest.
Post-resuscitation Survival was determined by the number surviving to hospital discharge divided by the number surviving the acute resuscitation.
Significant Disability was defined as the proportion of patients surviving to hospital discharge with a CPC Score of > 1.
Severe Disability was defined as the proportion of patients surviving to hospital discharge with a CPC Score of > 2.