Figure 1. Administration of rapamycin extends lifespan and delays carcinogenesis in p53+/− male mice.

(A) Kaplan Meier survival curve of rapamycin-treated (red line) and control (blue line) mice. (B) Incidence of tumors in rapamycin-treated (red) and control (blue) mice. Animals received rapamycin starting at various ages at 1.5 mg/kg per day in drinking water throughout entire life. * p<0.05. (C) Kaplan Meier survival curve of rapamycin-treated (red line) and control (blue line) mice that start receiving rapamycin early in life (<5 months). (D) Incidence of tumors in rapamycin-treated (red) and control (blue) mice that start receiving rapamycin early in life (<5 months). * p<0.05 toph