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. 2012 Oct 29;4(10):715–722. doi: 10.18632/aging.100496

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Copyright: © 2012 Comas et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited

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Rapatar delays development of lymphomas in p53^−/− mice. (A) Representative initial lymphoma developed in control mouse at the age of 101 days. (B) Similar appearance of lymphoma in Rapatar-treated mouse at 281 days of age. Both A and B show monotonous infiltrate of medium-sized neoplastic cells with round nuclei, fine chromatin, indistinct nucleoli, and numerous mitotic figures and apoptotic cells. (C) Advanced lymphoma in 134-day old control mouse with metastases in liver (D) and lung (E). (D) Metastasis in liver showing the extensive spread of neoplastic cells effaces the normal structure and only minimal remnants of hepatocytes (marked by arrows). (E) Metastasis in the lung showing neoplastic infiltrates in perivascular area and in the alveolar walls (arrows) (F) Advanced lymphoma with pathological changes similar to shown in C in the thymus of 241day-old Rapatar-treated animal with metastasis in liver (G) and lung (H). (G) Metastasis in liver showing neoplastic infiltrates in portal tract (yellow arrow) and sinusoids (white arrow). (H) Metastasis in the lung showing perivascular neoplastic infiltrate (arrow).