Table 1. Pharmacokinetic parameters of unformulated rapamycin and Rapatar in C57Bl/6J mice. Abbreviations: C_max – the peak concentration; T_max – time taken to reach peak concentration; AUC – area under the curve; F – absolute bioavailability.

	Units	Rapamycin, IV 0.4mg/kg	Rapatar, PO 4mg/kg
Dose amount	ng	10.4	104
Dosage	ng/kg	400	4000
Cmax	ng/ml	958	656
Tmax	hr	0.04	0.25
AUC	ng-hr/ml	2634.6	3161.5
Half-life	hr	6.4	N/A
F	%	100	12