Spontaneous bilateral EEG activity recorded from awake and behaving 3-6 month old adult (A) WT, (B) Elavl3+/-, and (C) Elavl3-/- mice. Cortical recordings are displayed from left (L-reference) and right (R-reference) hemisphere temporoparietal electrodes. WT mice lack abnormal discharges seen occurring intermittently in Elavl3+/- and Elavl3-/- mice. Brief seizures shown in Elavl3-/- mice are accompanied by mild convulsive clonic movements. Seizures were detected in both Elavl3-/- and -/+ mice. Calibration, 1 sec (A and C, 0.5 sec in B), 200 microvolts (A-C). See also Fig.S5-6, Tables S10-11 and Movie S1.