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. 2012 Dec 3;2012:324521. doi: 10.1155/2012/324521

Figure 1.

Figure 1

Domain structure and PD mutations of LRRK2. The central region of LRRK2 contains a GTPase domain also called (ROC), a C-terminal of ROC (COR) domain of unknown function, and a kinase domain, flanked on either side by protein-protein interaction domains including an ankyrin repeat domain (ANK), leucine-rich repeats (LRR) and a WD40 domain (WD40). Clearly causative pathogenic mutations are indicated and are clustered around the catalytic domains of LRRK2. Only the G2019S mutation consistently augments kinase activity.