Fig. 2.

Time course of [¹³C₆]-lysine incorporation in xenograft tumors. A, schematic of the analysis of heavy [¹³C₆]-lysine incorporation in mouse xenograft tumors. After subcutaneous injection of SRC-SW620 cells into the flanks of nude mice, animals were subjected to a heavy SILAC diet containing [¹³C₆]-lysine for 18 or 30 days (three animals for each time point). B, histogram showing the distribution of the incorporation ratios in tumor proteins after 18 days (left) and 30 days (right) in six different animals.