Fig. 3.

Overview of protein enrichment. Protein enrichment values were calculated for each protein in the synaptosomal (Syn), vesicular (Ves), parasynaptic (Para), and PSD fractions by normalizing measures in each fraction to protein measures in the total homogenate (Hom). The averages of these values for each fraction were then taken for the three human and three mouse samples and CV%s calculated. A, Reports the median CV% of protein enrichment values for each fraction. To sort out protein groups and fractions by enrichment value unsupervised hierarchical clustering, with Pearson's Correlation as the similarity metric, was used. B, Shows this clustering analysis of the mouse and human fractions as a heat map. synaptosomal (SF), vesicular (V), parasynaptic (P), and PSD (D).