Fig. 6.

Comparison of human and protein sequences. Protein sequences were retrieved for human and mouse homologenes from the total proteome and a representative synaptic proteome. Lysine containing peptides, between 6 and 25 amino acids in length were compared between the two species. This analysis shows that the [¹³C₆]brain ISTD can theoretically be used to quantify 80% of the human synaptic proteins identified by more than two peptides. Additionally, the vast majority of these synaptic proteins have peptides in the NIST Libraries of Peptide Tandem Mass Spectra.