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LAT2 is degraded by proteasomes after treatment with alkylphospholipids. A, 3-h treatment of NB4 cells before exposure to the proteasome inhibitor MG132 (10 μm) prevented the reduction of LAT2 induced by 25 μm ODPC. B, C, a similar effect was observed after exposure (30 min) of NB4 cells to the proteasome inhibitor MLN9708 (5 μm) followed by treatment with 25 μm ODPC (B) or 25 μm perifosine (C).
