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LAT2 knockdown NB4 cells (NB4 LAT2KD) have a lower proliferation potential and a higher sensitivity to APLs or ATO. A, NB4 LAT2KD cells have a lower proliferation potential than the parental NB4 cells, as determined by the doubling time, which is higher in NB4 LAT2KD. B–D, NB4 LAT2KD showed greater sensitivity to apoptosis induction by ATO (B), ODPC (C), and perifosine (D). Values in parentheses indicate the 95% CI.
