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. 2012 Sep 22;11(12):1898–1912. doi: 10.1074/mcp.M112.019661

Fig. 8.

Fig. 8.

Proposed mechanism of alkylphospholipid (ODPC)-induced raft-based inhibition of cell signaling. A, lipid rafts are membrane domains enriched in shingolipids (green) and cholesterol (blue) that serve as a scaffold for signaling through growth factor receptors (purple). The correct assembly of lipid rafts containing adaptor proteins such as LAT2 and Grb2 is essential for proper signaling of the AKT survival pathway (shown in A). Alkylphospholipids (ODPC) disrupt the assembly of lipid rafts, displacing raft-associated adaptor proteins. As a result, signal transduction is inhibited (shown in B). ODPC, 10-(octyloxy) decyl-2-(trimethylammonium) ethyl phosphate; PI3K, phosphatidylinositol 3-kinases; Grb2, growth factor receptor-bound protein 2; LAT2, linker for activation of T-cell family member 2; PTEN, phosphatase and tensin homolog; PDK1, phosphoinositide-dependent protein kinase 1); AKT, v-AKT murine thymoma viral oncogene homolog 1; PIP2, phosphatidylinositol (3,4)-bisphosphate; PIP3, phosphatidylinositol (3,4,5)-trisphosphate.