Table II. Effective dose 50% (ED50) of ATO, ODPC, or perifosine for the inhibition of the proliferation of NB4 wild type (NB4 WT) and LAT2 knockdown NB4 (NB4 LAT2KD) cells.
NB4 WT |
NB4 LAT2KD |
Relative drug susceptibilitya |
|||||
---|---|---|---|---|---|---|---|
ED50 (μm) | 95% CIb | r | ED50 (μm) | 95% CIb | r | NB4 WT/NB4 LAT2KD | |
ATO | 8.76 | 5.36 to 14.34 | 0.94 | 1.03 | 0.92 to 1.15 | 0.98 | 8.50 |
ODPC | 23.49 | 19.79 to 27.88 | 0.95 | 3.12 | 1.83 to 5.28 | 0.92 | 7.53 |
Perifosine | 18.67 | 16.48 to 21.17 | 0.97 | 6.10 | 4.45 to 8.37 | 0.91 | 3.06 |
a Ratio calculated by averaging ED50.
b 95% CI is the 95% confidence interval for ED50, expressed in μm.