TABLE 5.
Comparison of IF, WCE, and IB to determine accessibility of three inner core LPS MAbs (L2-16, LPT3-1, L3B5) to N. meningitidis strains and mutants
| MAb | Strain (immunotype) | Genotype | Result ofa
|
||
|---|---|---|---|---|---|
| IF | WCE (OD410) | IB | |||
| L2-16 | 35E (L2) | Wild type | + | 1.1 | +++ |
| galE | + | 0.98 | +++ | ||
| 89I (L4) | Wild type | − | 0.13 | − | |
| galE | + | 0.63 | +++ | ||
| LPT 3-1 | MC58 (L3) | Wild type | + | 0 | + |
| galE | + | 0.20 | + | ||
| lpt3 | + | 1.51 | +++ | ||
| lpt3 galE | + | 2.01 | +++ | ||
| L3B5 | MC58 (L3) | Wild type | + | 0.04 | + |
| galE | + | 0.58 | +++ | ||
a
Symbols: +, positive; +++, strongly positive; −, negative.