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. 2012 Aug 15;303(9):F1300–F1306. doi: 10.1152/ajprenal.00351.2012

Fig. 6.

Fig. 6.

PDE blockade with 10 μM IBMX significantly reduced 20-Hz electrical field stimulation (EFS)-induced phasic contractions of human UBSM-isolated strips. A: representative recording illustrating that PDE blockade suppressed the 20-Hz EFS-induced phasic contractions. B: summary data showing that PDE blockade reduced the 20-Hz EFS-induced UBSM contraction amplitude, muscle force integral, and duration (n = 5, N = 5; *P < 0.05 vs. control). C: representative recording showing that paxilline (1 μM) increased the 20-Hz EFS-induced phasic contractions and that the subsequent addition of 10 μM IBMX did not have any further effect on the contractions. D: summary data showing that 1 μM paxilline increased the 20-Hz EFS-induced contraction amplitude, muscle force integral, and duration and that the subsequent addition of 10 μM IBMX did not have any further effect on UBSM contraction parameters (n = 4, N = 4; *P < 0.05 vs. control; NS vs. paxilline).