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. 2012 Dec 10;199(6):893–906. doi: 10.1083/jcb.201207189

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© 2012 Conomos et al.

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Figure 6. — Incorporation of variant repeats into the telomeres induces ALT-associated characteristics. (A) Quantitation of meta-TIF analysis showing the percentage of chromosome ends stained with γ-H2AX on one or both chromatids in HT1080 cells expressing variant hTR compared with wild-type (mean ± SD; n = 3, quantifying >2,000 chromosome ends or ∼20 metaphases per replicate). (B) Quantitation of C-circle levels in HT1080 cells expressing wild-type and variant hTR in comparison to the IIICF/c ALT cell line (mean ± SD; n = 3) plotted on a logarithmic scale. (C) Representative metaphase spreads of the HT1080 hTR C- and G-type cells processed for neo^R-FISH showing no copying of the neo^R tag at early and late pds. Magnified examples are shown in the bottom right. Bars, 5 µm.