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. Author manuscript; available in PMC: 2012 Dec 10.
Published in final edited form as: Chem Biol. 2010 Dec 22;17(12):1275–1281. doi: 10.1016/j.chembiol.2010.07.018

Table I.

Structures and enzyme inhibition of the argifin-derived fragments.

graphic file with name emss-50663-t0003.jpg
R IC50 (μM)
1 CH3 79 ± 8
2 CH3CH2 310 ± 7
3 CH3(CH2)2 62 ± 1
4 CH3(CH2)3 38 ± 7
5 graphic file with name emss-50663-t0004.jpg 42 ± 1.3
6 Ph 112 ± 1
7 PhCH2 299 ± 4
graphic file with name emss-50663-t0005.jpg
allosamidin 		127 ± 14
argifin > 3.8 mM