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. Author manuscript; available in PMC: 2012 Dec 10.
Published in final edited form as: Biochem J. 2010 Feb 24;426(3):281–292. doi: 10.1042/BJ20091351

Figure 2. Multiple sequence alignment of the GT88 family members and TcdB.

Figure 2

GT88 members are LppGT, LppaGT (LpGT from strain Paris), LplGT, Lgt2 and Lgt3. Secondary structure elements from the LppGT structure are dark grey for the N-terminal domain, black for the central domain and light grey for the protrusion domain. Conserved catalytic glutamine residues are indicated with a black circle, the aspartic residues of the DxD motif are marked with a black star, amino acids interacting with UDP-glucose by direct hydrogen bonds or hydrophobic stacking interactions are highlighted with a black triangle, and amino acids interacting with UDP-glucose by indirect hydrogen bonds through water molecules are highlighted with a grey triangle.