Figure 4. Active site of LpGT bound to UDP-glucose and metals.

Stereo images of the LplGT, LppGT and TcdB active sites. LplGT is shown in complex with UDP-glucose and Mg²⁺. LppGT and TcdB crystal structures are shown in complex with UDP, glucose and Mn²⁺. The amino acids are shown as grey sticks. The ligands and metals are shown as green sticks and pink spheres respectively. Protein–ligand hydrogen bonds are shown as broken black lines. The distances between Asn²⁹³ and Asn⁴⁹⁹ to the anomeric carbon are shown as thin lines. Unbiased (i.e. before inclusion of any inhibitor model) F_o–F_c, ϕ_calc electron density maps are shown at 2.5 σ.