TABLE 2—
Factors Independently Associated With Hepatitis C Virus Seropositivity: Social Networks Among Appalachian People (SNAP) Study, 2008–2010
| Odds Ratioa (95% CI) | Adjusted Odds Ratiob (95% CI) | |
| Lifetime demographic factors | ||
| White (vs other race/ethnicity) | 2.16c (0.90, 5.21) | 2.22 (0.92, 5.35) |
| Education in years | 0.99 (0.98, 1.00) | … |
| DSM-IV psychiatric disorders | ||
| PTSD | 0.45* (0.25, 0.80) | 0.35** (0.19, 0.64) |
| ASPD | 0.69c (0.45, 1.06) | … |
| Methadone treatment | 1.76 (0.89, 3.48) | … |
| HSV-2 | 1.94c (1.07, 3.71) | 2.39* (1.13, 5.04) |
| Lifetime injection risk behaviors | ||
| Prescription opioid injection | 1.72c (0.91, 3.24) | 2.22* (1.13, 4.35) |
| Cocaine injection | 2.30** (1.47, 3.69) | 2.13** (1.31, 3.45) |
| Heroin injection | 1.68c (1.03, 2.75) | … |
| Years injecting (continuous) | 1.04* (1.01, 1.08) | … |
| Years injecting (categorical) | ||
| < 1 (Ref) | 1.00 | 1.00 |
| 1–2 | 1.92 (0.85, 4.32) | 1.55 (0.65, 3.73) |
| 1–3 | 1.50 (0.60, 3.74) | 1.40 (0.54, 3.60) |
| 1–5 | 1.90c (0.91, 3.95) | 1.55 (0.70, 3.41) |
| ≥ 5 | 3.51** (2.00, 6.18) | 3.08** (1.67, 5.66) |
| No. of sex partners (continuous) | 1.00 (0.99, 1.00) | … |
| OxyContin use | 3.53 (0.76, 16.1) | … |
| Current (prior 6 mo) factors | ||
| Injection risk behaviors | ||
| Syringe sharing | 2.26** (1.34, 3.08) | 2.24** (1.32, 3.82) |
| Cottons/cookers/water sharing | 1.84** (1.18, 2.87) | … |
| Drug network characteristics | ||
| Degree centralityd | 1.63c (0.98, 2.72) | … |
| Eigenvector centralitye | 1.07** (1.02, 1.12) | 1.07** (1.02, 1.12) |
Note. ASPD = antisocial personality disorder; CI = confidence interval; DSM-IV = Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition; HSV-2 = herpes simplex-2 virus; PTSD = posttraumatic stress disorder.
Adjusted for recruiter characteristics.
Adjusted for recruiter characteristics and all other variables in the model.
P value approached significance, and so variable was included in multivariable logistic regression model.
Degree centrality takes into account the number of links to and from a person.
Eigenvector centrality extends the notion of degree centrality to take into account second-order connections.
*P < .05; **P < .01.