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. Author manuscript; available in PMC: 2012 Dec 10.
Published in final edited form as: Nat Commun. 2012 Jan 10;3:614. doi: 10.1038/ncomms1629

Figure 3.

Figure 3

Construction and screening of the DNA:PNA-Yx multivalent library. a. Generation of the multivalent library by complexing each PNA in the first box with every DNA in the second box. PNA-A is an aegPNA oligomer with a c(RGDfK) bound to the N terminus. PNA-B, PNA-C and PNA-D have 1, 2 or 3 c(RGDfK) units respectively, conjugated via γ-sidechains of internal LKγ-PNA residues. DNA is numbered according to how many complementary sequences each contains and represents the number of PNAs that would be complexed. Inhibition of C32 cell adhesion to vitronectin was examined with DNA:PNA complexes. b. Three-dimensional representations of IC50 data from the screen of the library (A/B represents results from either PNA A or B). Data for DNA:PNA-C/D13–15 were not acquired because inhibitory activity was maximized at shorter lengths of ssDNA (see Supplementary Fig. S2 for error bars).