Table 4.
Associations between biomarker expression and clinical outcome in epithelial (E) and stromal (S) elements of metastatic or recurrent endometrial cancers.
| Biomarker | Progression-Free Survival | Overall Survival | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Unadjusted Model | Adjusted Model | Unadjusted Model | Adjusted Model | |||||||||
| HR | (95% CI) |
p | HR | (95% CI) |
p | HR | (95% CI) |
p | HR | (95% CI) |
p | |
| E-cadherin E | ||||||||||||
| T1: Low | 1.00 | NA | NA | 1.00 | NA | NA | 1.00 | NA | NA | 1.00 | NA | NA |
| T2: Moderate | 0.34 | (0.15, 0.76) | 0.008 | 0.30 | (0.10, 0.86) | 0.025 | 0.14 | (0.06, 0.37) | <.001 | 0.18 | (0.05, 0.59) | 0.004 |
| T3: High | 0.32 | (0.14, 0.73) | 0.006 | 0.44 | (0.16, 1.21) | 0.112 | 0.17 | (0.07, 0.42) | <.001 | 0.22 | (0.07, 0.70) | 0.010 |
| N-cadherin E | ||||||||||||
| T1: Low | 1.00 | NA | NA | 1.00 | NA | NA | 1.00 | NA | NA | 1.00 | NA | NA |
| T2: Moderate | 0.48 | (0.21, 1.08) | 0.076 | 0.60 | (0.22, 1.64) | 0.316 | 0.54 | (0.25, 1.18) | 0.122 | 0.65 | (0.24, 1.80) | 0.408 |
| T3: High | 0.63 | (0.29, 1.36) | 0.236 | 0.90 | (0.37, 2.16) | 0.807 | 0.33 | (0.14, 0.75) | 0.009 | 0.43 | (0.16, 1.17) | 0.097 |
| p120-cateninE | ||||||||||||
| T1: Low | 1.00 | NA | NA | 1.00 | NA | NA | 1.00 | NA | NA | 1.00 | NA | NA |
| T2: Moderate | 0.67 | (0.31, 1.44) | 0.302 | 1.05 | (0.41, 2.69) | 0.913 | 0.54 | (0.24, 1.20) | 0.129 | 0.47 | (0.16, 1.36) | 0.161 |
| T3: High | 0.76 | (0.35, 1.64) | 0.482 | 1.05 | (0.36, 3.11) | 0.928 | 0.44 | (0.20, 0.98) | 0.045 | 0.39 | (0.13, 1.18) | 0.096 |
| alpha-catenin E | ||||||||||||
| T1: Low | 1.00 | NA | NA | 1.00 | NA | NA | 1.00 | NA | NA | 1.00 | NA | NA |
| T2: Moderate | 1.47 | (0.68, 3.18) | 0.330 | 1.31 | (0.49, 3.52) | 0.587 | 1.27 | (0.56, 2.89) | 0.575 | 0.88 | (0.34, 2.26) | 0.790 |
| T3: High | 0.88 | (0.42, 1.86) | 0.738 | 0.69 | (0.22, 2.16) | 0.523 | 0.99 | (0.45, 2.20) | 0.981 | 0.54 | (0.18, 1.63) | 0.274 |
| beta-catenin E | ||||||||||||
| T1: Low | 1.00 | NA | NA | 1.00 | NA | NA | 1.00 | NA | NA | 1.00 | NA | NA |
| T2: Moderate | 1.03 | (0.48, 2.19) | 0.946 | 0.74 | (0.28, 1.98) | 0.549 | 1.37 | (0.62, 3.02) | 0.442 | 1.41 | (0.50, 3.95) | 0.511 |
| T3: High | 0.69 | (0.32, 1.48) | 0.342 | 0.60 | (0.22, 1.67) | 0.329 | 0.67 | (0.30, 1.50) | 0.333 | 0.48 | (0.16, 1.41) | 0.181 |
| gamma-cateninE | ||||||||||||
| T1: Low | 1.00 | NA | NA | 1.00 | NA | NA | 1.00 | NA | NA | 1.00 | NA | NA |
| T2: Moderate | 0.77 | (0.35, 1.70) | 0.519 | 1.24 | (0.48, 3.21) | 0.659 | 0.53 | (0.23, 1.20) | 0.128 | 0.48 | (0.19, 1.25) | 0.134 |
| T3: High | 0.55 | (0.26, 1.19) | 0.131 | 0.46 | (0.17, 1.24) | 0.125 | 0.59 | (0.27, 1.28) | 0.182 | 0.36 | (0.12, 1.03) | 0.057 |
| Ki67E | ||||||||||||
| T1: Low | 1.00 | NA | NA | 1.00 | NA | NA | 1.00 | NA | NA | 1.00 | NA | NA |
| T2: Moderate | 0.82 | (0.38, 1.76) | 0.615 | 0.81 | (0.33, 2.01) | 0.649 | 0.65 | (0.29, 1.46) | 0.294 | 0.48 | (0.18, 1.30) | 0.149 |
| T3: High | 1.07 | (0.51, 2.27) | 0.859 | 0.77 | (0.28, 2.14) | 0.618 | 1.06 | (0.49, 2.32) | 0.883 | 0.59 | (0.22, 1.59) | 0.299 |
| p16E | ||||||||||||
| Negative | 1.00 | NA | NA | 1.00 | NA | NA | 1.00 | NA | NA | 1.00 | NA | NA |
| Below median: low | 0.83 | (0.38, 1.80) | 0.636 | 0.34 | (0.08, 1.36) | 0.125 | 0.99 | (0.44, 2.22) | 0.975 | 0.39 | (0.09, 1.62) | 0.196 |
| Above median: high | 1.54 | (0.73, 3.27) | 0.258 | 2.02 | (0.67, 6.05) | 0.209 | 3.87 | (1.74, 8.61) | <.001 | 4.18 | (1.28, 13.6) | 0.018 |
| p27E | ||||||||||||
| Negative | 1.00 | NA | NA | 1.00 | NA | NA | 1.00 | NA | NA | 1.00 | NA | NA |
| Below median: low | 1.12 | (0.53, 2.39) | 0.766 | 0.54 | (0.17, 1.79) | 0.316 | 1.70 | (0.79, 3.70) | 0.177 | 0.92 | (0.29, 2.95) | 0.893 |
| Above median: high | 0.64 | (0.30, 1.37) | 0.248 | 0.35 | (0.12, 1.04) | 0.058 | 0.68 | (0.30, 1.54) | 0.350 | 0.51 | (0.18, 1.41) | 0.191 |
| p53E | ||||||||||||
| Negative | 1.00 | NA | NA | 1.00 | NA | NA | 1.00 | NA | NA | 1.00 | NA | NA |
| Positive | 1.28 | (0.66, 2.50) | 0.461 | 1.28 | (0.53, 3.07) | 0.584 | 2.31 | (1.16, 4.60) | 0.018* | 1.99 | (0.78, 5.07) | 0.150 |
| Ki-67S | ||||||||||||
| Negative | 1.00 | NA | NA | 1.00 | NA | NA | 1.00 | NA | NA | 1.00 | NA | NA |
| Positive | 1.35 | (0.72, 2.55) | 0.349 | 0.87 | (0.39, 1.91) | 0.723 | 1.03 | (0.54, 1.95) | 0.934 | 0.97 | (0.41, 2.30) | 0.947 |
| APCS | ||||||||||||
| Negative | 1.00 | NA | NA | 1.00 | NA | NA | 1.00 | NA | NA | 1.00 | NA | NA |
| Positive | 1.97 | (0.97, 4.00) | 0.060 | 1.92 | (0.69, 5.28) | 0.210 | 1.41 | (0.70, 2.80) | 0.334 | 1.65 | (0.70, 3.90) | 0.254 |
| CD44S | ||||||||||||
| Negative | 1.00 | NA | NA | 1.00 | NA | NA | 1.00 | NA | NA | 1.00 | NA | NA |
| Below median: low | 1.55 | (0.61, 3.96) | 0.356 | 1.26 | (0.33, 4.81) | 0.739 | 1.13 | (0.43, 2.96) | 0.809 | 0.91 | (0.23, 3.51) | 0.886 |
| Above median: high | 2.23 | (0.85, 5.85) | 0.105 | 1.33 | (0.36, 5.00) | 0.670 | 1.22 | (0.48, 3.11) | 0.681 | 1.25 | (0.32, 4.88) | 0.749 |
Categorized biomarker expression (percent staining × intensity).
NA: not applicable
Estimated hazard ratio (HR) and 95% confidence interval (95% CI) for Cox regression analysis.
†
with an adjustment for patient age at study enrollment and stratification for performance status and tumor grade.
When the 95% CI does not overlap a HR of 1.0, the association was significant (p<0.05 are bolded).