Table 3.
Nominally significant associations with cognitive and behavioral reading and cognitive measures
| Task | Variant | Gene | Direction of Effecta | P-valuec |
|---|---|---|---|---|
| WASIVIQ | rsSTR (allele 5) | DCDC2 | 18.491 | 0.019 |
| WASIVIQ | rsSTR (allele 6) | DCDC2 | -21.092 | 0.0194 |
| WASIPIQ | rs807724 | DCDC2 | 6.264 | 0.0359 |
| WJBAR | rsSTR (allele 1) | DCDC2 | 6.4 | 0.0291 |
| WJLW | rsSTR (allele 1) | DCDC2 | 7.63 | 0.0197 |
| WJPC | rsSTR (allele 1) | DCDC2 | 6.981 | 0.0289 |
| WJPC | rsSTR (allele 10) | DCDC2 | -10.69 | 0.0328 |
| WJSP | rsSTR (allele 1) | DCDC2 | 9.872 | 0.0099 |
| GORTAC | rs807701 | DCDC2 | 1.417 | 0.035 |
| GORTCP | rs807701 | DCDC2 | 1.195 | 0.0411 |
| GORTCP | rs807724 | DCDC2 | 1.642 | 0.0221 |
| GORTCP | rsSTR (allele 1) | DCDC2 | 1.985 | 0.0028 |
| CTOPPBW | rs6935076 | KIAA0319 | -0.881 | 0.049 |
| CTOPPMD | rsSTR (allele 3) | DCDC2 | 3.399 | 0.0308 |
| CTOPPRD | rsdelb | DCDC2 | 1.629 | 0.0263 |
| CTOPPRD | rsSTR (allele10) | DCDC2 | -2.021 | 0.011 |
a
For SNPs, the direction of effect refers to allele 1 (see Supplementary Table S3), allele 2 has the opposite effect.
b
Biallelic association (presence/absence of the BV677278 deletion)
c
No p-value remained significant following correction for multiple testing (437 tests performed).