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. 2012 Dec 15;139(24):4623–4632. doi: 10.1242/dev.086645

Fig. 3.

Fig. 3.

Tcfap2c regulates genes that are crucial for cell polarity, TJ assembly and ion gradients. (A) qRT-PCR analysis of Tcfap2c target genes in Tcfap2c KD and control morulae (90 hph). Genes important for cell polarity, tight junction (TJ) assembly and fluid gradient were significantly downregulated in Tcfap2c KD embryos. Error bars indicate mean ± s.e.m. *P<0.05. (B) Protein expression and localization of Tcfap2c target genes in Tcfap2c KD and control morulae. Depletion of Tcfap2c disrupted the expression and subcellular localization of Pard6b, Cldn4, Aqp3, Krt18, Tjp2 and F-actin. Embryos were counterstained with DAPI.