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. 2012 Dec 15;139(24):4623–4632. doi: 10.1242/dev.086645

Fig. 6.

Fig. 6.

Tcfap2c regulates cellular proliferation via direct repression of p21. (A) ChIP analysis of Tcfap2c binding to the p21 proximal promoter. (B) p21 is upregulated in Tcfap2c KD morulae. Upregulation of p21 is independent of p53 and Hdac1 expression. (C) Expression and subcellular localization of p21 protein in Tcfap2c KD and control morulae. (D) Combined KD of p21 and Tcfap2c partially rescues blastocyst formation. (E) Representative brightfield and fluorescence images of p21/Tcfap2c KD and control blastocysts subjected to the FITC-dextran assay. Error bars indicate s.e.m.