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. Author manuscript; available in PMC: 2013 Nov 26.
Published in final edited form as: J Med Chem. 2012 Nov 6;55(22):9946–9957. doi: 10.1021/jm301144g

Figure 4. Effect of stereochemistry of 1,4-DHPs 1, 23 and 43 on TGFβ and Activin A inhibition.

Figure 4

A) Dose-response profiles of (+)- and (−) enantiomers for TGFβ and Activin A inhibition; B) Table of TGFβ and Activin A inhibition parameters, data represent means ± SD of n = 2–5 independent experiments. SB = SB-431542, a literature reported TGFβ inhibitor (Alk 4/5/7 inhibitor).21