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. Author manuscript; available in PMC: 2013 Nov 26.
Published in final edited form as: J Med Chem. 2012 Nov 6;55(22):9946–9957. doi: 10.1021/jm301144g

Table 3.

Effect of the R3 region on TGFβ inhibition.agraphic file with name nihms-419834-t0018.jpg

compd R3 IC50 (μM) %inhibition (2.5 μM)
1 Me 0.85 ± 0.30 83 ± 8
20 nPr 0.83 ± 0.09 88 ± 1
a

Data represent means ± SD of n = 2–4 independent experiments.