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. Author manuscript; available in PMC: 2013 Nov 26.
Published in final edited form as: J Med Chem. 2012 Nov 6;55(22):9946–9957. doi: 10.1021/jm301144g

Table 5.

Effect of SAR-optimized substitution pattern on TGFβ inhibition.agraphic file with name nihms-419834-t0020.jpg

compd R IC50 (μM) %inhibition (2.5 μM)
28 Et 0.17 ± 0.05 98 ± 1
29 iBu 0.17 ± 0.02 94 ± 1
a

Data represent means ± SD of n = 2–4 independent experiments.