Table 1. Selected baseline demographics of ADDITION-Leicester cohort investigated, separated by ethnicity and sex.
| White Europeans (n = 505) | South Asian (n = 224) | |||
| Men (n = 255) | Women (n = 250) | Men (n = 124) | Women (n = 100) | |
| Age (years) | 60.4 (9.0) | 62.1 (8.9)† | 52.2 (10.4) | 52.1 (9.9) |
| Deprivation level score | 14.7 (13.5–16.0) | 15.1 (13.8–16.5) | 19.6 (16.9–25.3) | 21.0 (14.1–26.7) |
| Height (m) | 1.75 (0.1) | 1.60 (0.1)* | 1.69 (0.1) | 1.54 (0.1)* |
| Weight (kg) | 90.9 (15.2) | 77.6 (15.0)* | 77.0 (12.2) | 72.1 (14.3)‡ |
| Body Mass Index (kg/m2) | 29.5 (4.2) | 30.1 (5.5) | 27.0 (3.6) | 30.2 (5.4)* |
| Waist Circumference (cm) | 104.0 (11.2) | 94.3 (13.6)* | 96.4 (9.3) | 92.7 (12.3)† |
| Systolic blood pressure (mmHg) | 143.9 (18.1) | 141.9 (20.5) | 140.6 (18.0) | 133.5 (21.9)† |
| Diastolic blood pressure (mmHg) | 88.7 (9.5) | 85.8 (10.9)‡ | 88.7 (11.3) | 85.2 (10.8)† |
| Creatinine (µmol/l) | 94.0 (11.7) | 79.1 (11.2)* | 94.7 (13.8) | 74.1 (8.8)* |
| Triglycerides (mmol/l) | 1.4 (1.3–1.5) | 1.3 (1.2–1.4) | 1.5 (1.3–1.6) | 1.3 (1.1–1.4)† |
| HDL cholesterol (mmol/l) | 1.2 (1.2–1.3) | 1.5 (1.4–1.5)* | 1.2 (1.1–1.2) | 1.3 (1.2–1.3)† |
| Triglyceride-to-HDL-Cholesterol ratio | 1.2 (1.1–1.3) | 0.9 (0.9–1.0)* | 1.3 (1.1–1.4) | 1.0 (0.9–1.1)† |
| LDL cholesterol (mmol/l) | 3.8 (0.9) | 3.9 (1.0) | 3.6 (0.9) | 3.2 (0.7)* |
| Fasting plasma glucose (mmol/l) | 5.9 (1.8) | 5.5 (1.1)‡ | 5.8 (1.5) | 5.5 (1.4) |
| 2 hour plasma glucose (mmol/l) | 7.6 (4.0) | 7.6 (3.4) | 8.0 (4.5) | 7.8 (3.3) |
| Fasting Insulin (µIU/ml) | 7.6 (7.0–8.2) | 6.9 (6.4–7.5) | 8.7 (7.8–9.8) | 8.7 (7.7–9.7) |
| HOMA1-IR | 1.9 (1.7–2.1) | 1.7 (1.5–1.8)‡ | 2.2 (1.9–2.5) | 2.1 (1.8–2.4) |
| QUICKI | 0.62 (0.61–0.64) | 0.65 (0.63–0.67)‡ | 0.60 (0.58–0.63) | 0.61 (0.59–0.63) |
| Glucose: Insulin ratio | ||||
| % High triglyceride ≥1.7 mmol/l | 33.3 | 30.0 | 40.3 | 22.4‡ |
| % Low HDL | 11.4 | 24.0* | 16.9 | 48.0* |
Continuous variables presented as mean (standard deviation) or geometric mean (95% confidence intervals) after initial log transformation of non-normally distributed variables. Low HDL defined <1.0 and 1.3 mmol/l in males and females respectively.
*
p<0.001,
‡
p<0.01,
†
p<0.05.