Table 2. Factors influencing overall survival by univariate and multivariate Cox-regression analysis.

Variable	Death		Univariate analysis			Multivariate analysis
	No.a	%	HR	95% CI	p -value	HR	95% CI	p -valueb
Gender
Male	50	44.6	1	Reference	_	1	Reference	_
Female	21	41.2	0.878	0.526–1.465	0.618	0.983	0.566–1.706	0.951
Subtype b
Precursor T	13	46.4	1	Reference	_	1	Reference	_
Mature T	58	43.0	0.590	0.318–1.096	0.095	0.626	0.330–1.190	0.153
IPI c
0	8	19.5	1	Reference	_	1	Reference	_
1	31	52.5	3.247	1.487–7.094	0.003	3.604	1.629–7.972	0.002
2	19	47.5	2.871	1.247–6.610	0.013	2.392	1.021–5.603	0.045
3	9	64.3	5.949	2.274–15.558	<0.000	6.331	2.383–16.825	<0.000
4	3	75.0	5.716	1.499–21.791	0.011	6.053	1.541–23.783	0.010
rs9514828
CC	18	48.6	1	Reference	_	1	Reference	_
CT	46	46.0	0.569	0.327–0.991	0.046	0.510	0.284–0.914	0.024
TT	7	26.9	0.351	0.146–0.844	0.019	0.394	0.159–0.980	0.045
rs3742330
GG	1	8.3	1	Reference	_	1	Reference	_
GA	31	44.3	6.291	0.858–46.119	0.070	8.956	1.210–66.318	0.032
AA	39	48.1	7.596	1.042–55.368	0.045	10.145	1.371–75.084	0.023

Abbreviation: HR, hazard ration; CI, confidence interval; IPI, International Prognostic Index.

^aNumber of patients.

^bPrecursor T comprising of T-lymphoblastic lymphoma/leukemia; Mature T comprising of peripheral T-cell lymphoma not otherwise specified, natural killer/T-cell lymphoma, anaplastic large-cell lymphoma, angioimmunoblastic T-cell lymphoma, mycosis fungoides, enteropathy-type intestinal T-cell lymphoma, Lenert's lymphoma and subcutaneous panniculitis-like T-cell lymphoma.

^cIPI score is based on the presence or absence of five adverse prognostic factors including age ≥60 years, Ann Arbor stage III or IV, serum lactate dehydrogenase (LDH) levels elevated, Eastern Cooperative Oncology Group (ECOG) performance status (PS) ≥2, and >1 site of extranodal involvement. The presence of each above item adds one score to IPI.