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. Author manuscript; available in PMC: 2012 Dec 10.
Published in final edited form as: Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2010 Jul-Aug;2(4):418–430. doi: 10.1002/wnan.95

FIGURE 2.

FIGURE 2

(a) Upper: Four types of engineered hemoglobin (Hb): (1) Polyhemoglobin (PolyHb) based on nanobiotechnology, (2) conjugated Hb, (3) intramolecularly crosslinked Hb, and (4) recombinant Hb. (b) Lower right: Larger complexes, like PolyHb and conjugated Hb cannot cross the intercellular junctions of the endothelial lining of vascular wall. Lower left: Small single Hb molecules, such as intramolecularly crosslinked Hb and recombinant Hb, can cross and bind and remove the nitric oxide needed for maintaining the normal tone of smooth muscles. This results in the constriction of blood vessels (Reprinted with permission from Ref 5. Copyright 2007 Taylor & Francis).