Histology of liver in rats toploaded with nanoartificial red blood cell (RBC) (a), LactRing (b), SF-Hb (c), polyhemoglobin (PolyHb) (d), or RBC (e). Under light microscope, there was no abnormality in Groups a, b, d, and e. For Group c infused with SF-Hb, there is hemoglobin (Hb) accumulation and steatmotosis. H&E staining, × 400 (Reprinted with permission from Ref 37. Copyright 2008 Taylor & Francis).