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. Author manuscript; available in PMC: 2012 Dec 10.
Published in final edited form as: Adv Exp Med Biol. 2012;751:139–156. doi: 10.1007/978-1-4614-3567-9_7

Fig. 7.4. Evolution of epistatic interactions within and between modules.

Fig. 7.4

We compared the genetic interactions within and between modules for the SWR-C, HIR-C, and SET3-C complexes in S. cerevisiae and S. pombe. These illustrate the general trend that genetic interactions within complexes tend to be conserved across species while the genetic interactions between complexes diverge at a higher rate. In this example the positive genetic interactions measured within the SWR-C complex subunits is highly conserved between S. cerevisiae and S. pombe, while the negative genetic interactions between SWR-C and HIR-C and between SET3-C and HIR-C observed in S. pombe are not conserved in S. cerevisiae