Table 7.1.
List of the first large-scale protein–protein, epistatic, and chemical–genetic interaction networks in different species. We collected from the literature the first large-scale networks reported for different model organisms. For each study we report the method used, the species studied, and the total number of interactions identified or quantified
| Interaction type | Method | Species | Interactions total (higher confidence) | Year | Reference |
|---|---|---|---|---|---|
| Protein–protein | Yeast-two-hybrid | S. cerevisiae | 183 | 2000 | [88] |
| S. cerevisiae | 957 | 2000 | [89] | ||
| D. melanogaster | 20,405 (4780) | 2004 | [90] | ||
| C. elegans | ~ 4,000 | 2004 | [91] | ||
| H. sapiens | 3,186 (911) | 2005 | [92] | ||
| H. sapiens | ~ 2,800 | 2005 | [93] | ||
| AP-MS | S. cerevisiae | 3,610 | 2002 | [94] | |
| S. cerevisiae | 7,123 | 2002 | [95] | ||
| S. cerevisiae | 589 protein assemblies | 2002 | [96] | ||
| H. sapiens | 6,463 (2.251) | 2007 | [97] | ||
| E. coli | 5,254 | 2005 | [98] | ||
| D. melanogaster | 556 protein assemblies | 2011 | [99] | ||
| HIV-H. sapiens | 497 | 2011 | [100] | ||
| Epistatic | SGA | S. cerevisiae | ~ 4,000 | 2001 | [46] |
| E-MAP | S. cerevisiae | ~ 180,000 quantifications | 2005 | [48] | |
| RNAi | C. elegans | ~ 65,000 quantifications | 2006 | [59] | |
| E-MAP | S. pombe | ~ 118,000 quantifications | 2008 | [57] | |
| SGA | S. pombe | ~ 49,000 quantifications | 2008 | [58] | |
| RNAi | D. melanogaster | ~ 70,000 quantifications | 2011 | [60] | |
| Chemical-genetic | Pooled growth | S. cerevisiae | 6 conditions X 5,916 genes | 2002 | [44] |
| Colony size | S. pombe | 21 conditions X 438 genes | 2010 | [76] | |
| Colony size | E. coli | 324 conditions X 3,979 mutants | 2010 | [69] |