Table 2. Inflammatory gene expression in lipopolysaccharide-activated wild type and ARF-deficient macrophages.
| Symbol |
Description |
Fold change |
|
|---|---|---|---|
| WT | Arf−/− | ||
| Casp1 |
Caspase 1 |
2,3858 |
3,6185 |
| Ccl12 |
Chemokine (C-C motif) ligand 12 |
339,1902 |
293,5526 |
| Ccl17 |
Chemokine (C-C motif) ligand 17 |
15,46 |
31,5263 |
| Ccl2 |
Chemokine (C-C motif) ligand 2 |
37,6895 |
49,6193 |
| Ccl22 |
Chemokine (C-C motif) ligand 22 |
47,0971 |
17,1265 |
| Ccl3 |
Chemokine (C-C motif) ligand 3 |
65,9904 |
36,7995 |
| Ccl4 |
Chemokine (C-C motif) ligand 4 |
92,4702 |
40,9398 |
| Ccl5 |
Chemokine (C-C motif) ligand 5 |
480,1318 |
618,0507 |
| Ccl7 |
Chemokine (C-C motif) ligand 7 |
95,9741 |
50,8313 |
| Ccl8 |
Chemokine (C-C motif) ligand 8 |
0,9048 |
2,4129 |
| Ccl9 |
Chemokine (C-C motif) ligand 9 |
18,802 |
6,4933 |
| Ccr4 |
Chemokine (C-C motif) receptor 4 |
4,175 |
0,5347 |
| Ccr9 |
Chemokine (C-C motif) receptor 9 |
8,9115 |
5,7009 |
| Cxcl1 |
Chemokine (C-X-C motif) ligand 1 |
423,505 |
197,4882 |
| Cxcl10 |
Chemokine (C-X-C motif) ligand 10 |
639,2351 |
465,289 |
| Cxcl9 |
Chemokine (C-X-C motif) ligand 9 |
184,895 |
123,7246 |
| Ifng |
Interferon gamma |
11,0909 |
3,6384 |
| Il10 |
Interleukin 10 |
4,7143 |
1,6302 |
| Il10ra |
Interleukin 10 receptor, α |
0,9859 |
2,2415 |
| Il13ra1 |
Interleukin 13 receptor, α 1 |
1,8425 |
3,7824 |
| Il15 |
Interleukin 15 |
19,8637 |
12,7172 |
| Il18 |
Interleukin 18 |
5,4358 |
5,6541 |
| Il1a |
Interleukin 1 α |
55,0694 |
44,468 |
| Il1b |
Interleukin 1 β |
2002,2656 |
1885,7737 |
| Il2rb |
Interleukin 2 receptor, β chain |
4,6718 |
3,2719 |
| Il2rg |
Interleukin 2 receptor, gamma chain |
2,4378 |
3,1741 |
| Il5ra |
Interleukin 5 receptor, α |
2,5791 |
3,6383 |
| Lta |
Lymphotoxin A |
12,0863 |
10,4605 |
| Ltb |
Lymphotoxin B |
7,0985 |
10,909 |
| Tnf |
Tumor necrosis factor |
465,9427 |
189,7928 |
| Tnfrsf1a |
Tumor necrosis factor receptor superfamily, member 1a |
2,0311 |
1,8406 |
| Tnfrsf1b |
Tumor necrosis factor receptor superfamily, member 1b |
13,7323 |
10,1068 |
| Xcr1 | Chemokine (C motif) receptor 1 | 3,5155 | 1,3856 |
Peritoneal macrophages from wild type (WT) and Arf−/− mice were obtained as described in Material and Methods. Cells were stimulated with 200 ng/mL lipopolysaccharide (LPS) for 6h and the expression of pro-inflammatory genes was analyzed by RT2 PCR analysis. Genes upregulated in LPS-stimulated Arf−/− cells as compared with WT cells are shown in bold.