Figure 7. Improvement of antitumor efficacy of high-affinity CD8+ T cells by the presence of tumor-specific CD4+ T cells. 8–9 week old RIP-Tag2-HA mice were immunized with peptide and polyI:C in IFA and Clone 4 cells (A–B: 2 × 105, C–D: 3 × 104) with or without 2 × 105 SFE cells were injected i.v.. Glucose levels in the blood were measured at the indicated time points, and each line represents one mouse. Data are representative of two independent experiments. (A) compared with (B): p < 0.05, (C) compared with (D): p < 0.0005.