Table 1. Currently known granzyme B functions.

Functions resulting in cytotoxicity	Non-cytotoxic functions
Cleavage of aspartic acid residues80	Cleavage of extracellular matrix proteins17-19
Target cell DNA fragmentation and caspase activation81-83	Cleavage of cell-surface receptors20-22
BID cleavage84 and processing of caspase 385	Regulatory functions23,24,45
AICD in T cells86-88 and NK cells41	Pro-inflammatory activity89
	Proteolysis of Von-Willebrandt factor25 and plasmin26
	Direct suppression of viral replication59,90
	Cleavage of autoantigens91
	Cleavage of IL-1α92

AICD, activation-induced cell death; IL-1α, interleukin-1α; NK, natural killer.