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. Author manuscript; available in PMC: 2013 Dec 15.
Published in final edited form as: J Immunol. 2012 Nov 9;189(12):5622–5631. doi: 10.4049/jimmunol.1200709

Figure 7. Local TLR7 ligation and TCM transfer is able to overcome tolerogenic environments and instate cutaneous immunotherapy.

Figure 7

A. CD11c.OVA mice bearing two well-healed K5mOVA skin grafts were adoptively transferred with 105 TEM or TCM 6 weeks following grafting. At time of transfer one of the two grafts was treated with imiquimod whilst the other was treated with control cream. Data analysed by log rank test, n=7 for TCM, n=8 for TEM. ***p<0.001, ns = not significant. B. CD11c.OVA mice bearing well-healed K5mOVA skin grafts were adoptively transferred with 105 TCM. 30 days later grafts were treated with either imiquimod or control cream for 10 days. Data analysed by log rank test, n=8, ns = not significant.