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. Author manuscript; available in PMC: 2013 Dec 15.
Published in final edited form as: J Immunol. 2012 Nov 7;189(12):5582–5589. doi: 10.4049/jimmunol.1200487

Figure 3. Inhibition of B7-CD28 interaction can prevent OSGE-mediated restoration of Glut-1, pAKT, CD69, and ICOS in adoptively transferred CD4 T cells from old mice.

Figure 3

B10.BR host mice were untreated or treated with CTLA4Ig prior the adoptive transfer of CD4 T cells from young and old AND mice treated with OSGE or vehicle. Glut-1, pAKT(308), CD69, and ICOS were analyzed 18 hours later by flow cytometry as described in Figure 2. Each bar represents the mean percentage (± SEM) of CD4 T cells from 3 independent experiments, with a total of 3 young and 3 old AND donor mice. The asterisk (*) indicates statistically significant declines in the CD4 response from old mice, while the (^) represents statistically significant inhibition of the OSGE-mediated restoration of these processes by CTLA4Ig treatment of CD4 T cells from old mice.