Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
(a) Generation of methylthiazolyl-S-thiolation domain intermediate at the start of the epothilone biosynthetic assembly line from acetyl- and Cys thioesters. The FAD-dependent oxidase domain converts methylthiazoline to methylthiazole; (b) tandem conversion of adjacent Cys residues to the bithiazolyl unit in the DNA-damaging antitumor antibiotic bleomycin.
