Table 3.

Voxel-based morphometric analyses examining the relationship between serum anticholinergicity and gray matter morphology in early course schizophrenia patients

MNI coordinates (x,y,z)	Cluster size	Location	BA	z	p	pFDR	Direction
−4, 44, 4	6637	Bilateral medial prefrontal cortex, bilateral anterior cingulate cortex, bilateral orbitofrontal cortex, right dorsolateral prefrontal cortex	8/9/10/11/32/46	4.67	<0.001	0.004	Negative
−46, 36, 16	1050	Left ventromedial prefrontal cortex, left dorsolateral prefrontal cortex	10/46/47	4.47	<0.001	0.004	Negative
−32, −6, −2	477	Left putamen	-	4.56	<0.001	0.004	Negative
−46, 6, 52	440	Left premotor and secondary motor cortex, left middle frontal gyrus	6	3.37	<0.001	0.009	Negative
−12, −14, −18	271	Left hippocampal complex	28/34	3.58	<0.001	0.006	Negative
−2, −20, −4	248	Midbrain	-	2.98	0.001	0.016	Negative
12, −14, −18	154	Right hippocampal complex	28/34	3.74	<0.001	0.005	Negative
34, 12, 40	100	Right middle frontal gyrus	8/9	3.24	0.001	0.011	Negative
26, 6, 8	98	Right putamen	-	2.91	0.002	0.017	Negative
−18, 38, 52	44	Left superior frontal gyrus	8	2.77	0.003	0.021	Negative

Note. In the above analysis, p is the uncorrected significance level and pFDR is the voxel-wise corrected significance threshold value.

BA = Brodmann’s Area