Table 2.
The association between pathologic characteristics of benign breast biopsies and subsequent breast cancer risk in African American women in Detroit, MI.
| Breast Cancer Status | Relative Riska | |||
|---|---|---|---|---|
| Negative | Positive | (95% C.I.) | p value | |
| Apocrine Metaplasia | ||||
| No | 927 | 38 | 1.0 (Ref) | |
| Yes | 422 | 17 | 0.93 (0.52-1.67) | 0.80 |
| Ductal Hyperplasia | ||||
| None | 928 | 36 | 1.0 (Ref) | |
| Yes | 415 | 19 | 1.14 (0.64-2.01) | 0.66 |
| Lobular Hyperplasia | ||||
| No | 1330 | 54 | 1.0 (Ref) | |
| Yes | 21 | 1 | 1.08 (0.14-8.21) | 0.94 |
| Cyst | ||||
| No | 809 | 28 | 1.0 (Ref) | |
| Yes | 540 | 27 | 1.41 (0.82-2.42) | 0.21 |
| Duct Ectasia | ||||
| No | 1294 | 52 | 1.0 (Ref) | |
| Yes | 57 | 3 | 1.33 (0.40-4.41) | 0.64 |
| Fibrosis | ||||
| No | 505 | 21 | 1.0 (Ref) | |
| Yes | 749 | 31 | 0.97 (0.55-1.71) | 0.91 |
| Intra-Ductal Papilloma | ||||
| None | 1220 | 48 | 1.0 (Ref) | |
| 1 or more | 130 | 7 | 1.26 (0.55-2.84) | 0.59 |
| Sclerosing adenosis | ||||
| No | 1266 | 48 | 1.0 (Ref) | |
| Yes | 84 | 7 | 2.20 (0.96-5.01) | 0.06 |
| Columnar alteration | ||||
| No | 1127 | 40 | 1.0 (Ref) | |
| Yes | 222 | 15 | 1.84 (0.99-3.39) | 0.05 |
| Atrophy | ||||
| None | 237 | 11 | 1.0 (Ref) | |
| Partial | 700 | 27 | 0.75 (0.37-1.55) | 0.44 |
| Complete | 218 | 12 | 0.84 (0.34-2.07) | 0.71 |
| Overall Impression | ||||
| Non-Proliferative Disease | 912 | 33 | 1.0 (Ref) | |
| Proliferative Disease without Atypia | 388 | 17 | 1.16 (0.64-2.12) | 0.62 |
| Proliferative Disease with Atypia | 39 | 5 | 3.29 (1.21-8.93) | 0.02 |
a
adjusted for age and year at biopsy