Table 2.
The effect of to expression on male life span.
| Driver | Mean LS (vs. ctrl) |
Mean LS extension |
Median LS (vs. ctrl) |
Median LS extension |
Max LS (vs. ctrl) |
Max LS extension |
Number of flies (control; experimental) |
χ2 | p-value |
|---|---|---|---|---|---|---|---|---|---|
| to-Gal4 | 53/50 | 6% | 60/54 | 11% | 76/66 | 15% | 175 202 |
30.58 | <0.0001 |
| to-Gal4 | 52/44 | 18% | 54/42 | 29% | 70/70 | 0% | 250 236 |
12.36 | 0.0004 |
| to-Gal4 + MP | 50/51 | −2% | 52/52 | 0% | 70/72 | −3% | 240 241 |
0.4388 | 0.5077 |
| S1-106, 100µM | 66/68 | −3% | 72/68 | 6% | 88/86 | 2% | 224 209 |
0.621 | 0.4307 |
| S1-106, 500µM | 70/68 | 3% | 76/68 | 12% | 96/86 | 12% | 224 215 |
28.78 | <0.0001 |
| S1-32, 100µM | 65/67 | −3% | 70/70 | 0% | 90/88 | 2% | 211 215 |
4.724 | 0.0297 |
| S1-32, 500µM | 61/67 | −9% | 68/70 | −3% | 83/90 | −8% | 211 150 |
22.39 | <0.0001 |
| S1-32, 100µM | 69/67 | 3% | 72/70 | 3% | 93/92 | 1% | 211 200 |
1.361 | 0.2434 |
| S1-32, 500µM | 68/67 | 1% | 70/70 | 0% | 94/92 | 2% | 211 174 |
2.077 | 0.1495 |
| S1-32 | 66/61 | 8% | 66/66 | 0% | 86/84 | 2% | 197 220 |
0.9982 | 0.3178 |
| S1-32 + MP | 70/64 | 9% | 78/70 | 11% | 90/90 | 0% | 224 211 |
3.634 | 0.0566 |
Log rank analysis of the survivorship curves of male flies. Mean, median and maximum lifespan, log rank analysis, p-value, percent change in mean, median and maximum lifespan as compared to controls (without RU486 for GeneSwitch experiments), Chi-square and p-values derived from the survivorship curves for each indicated intervention are shown. Maximum life span was calculated as the median life span of the longest surviving 10% of the population.