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. Author manuscript; available in PMC: 2014 Feb 1.
Published in final edited form as: Biomaterials. 2012 Nov 23;34(5):1529–1536. doi: 10.1016/j.biomaterials.2012.10.070

Figure 5. Model for Scaffold Implantation in Clinically Relevant Contusive Spinal Cord Injury.

Figure 5

(A) Human spinal cord injuries result in oval cystic lesion cavities that interrupt projecting axons (red) and cause demyelination. Scaffold implantation into this type of lesion would involve (B) placement of a dorsal linear incision in the spinal cord to provide a window for scaffold implantation, and (C) insertion of the scaffold. Because the original lesion is oval shaped, scaffolds would either need to be fabricated in a manner to match the shape of the lesion, or placed in a manner to occupy less than the full volume of the lesion site (shown in this example). The interfaces would then be filled with a cell matrix.