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. Author manuscript; available in PMC: 2013 Dec 15.
Published in final edited form as: J Immunol. 2012 Nov 9;189(12):5667–5681. doi: 10.4049/jimmunol.1201661

Figure 8. Elevated ANA-specific AFCs in female B6.Sle1b mice correlated with increased ANA-specific Ab titers.

Figure 8

Total double-stranded DNA- (A), histone- (B), and nucleosome- (C) specific serum Ab titers were measured by ELISA in 6–9 month old, sex matched B6 and B6.Sle1b mice. Similarly, ds-DNA-(D), histone- (E) and nuclesosome (F and G)-reactive and IgG subclass-IgG2c/2b-specific ANA titers were measured in mice described in (A–C). Only the ANA-specific IgG subclasses that had elevated levels of Ab titers above baseline are shown. The degree of correlation between the percentage of Spt-GC B cells and IgG2c-2b specific and double-stranded DNA- (H), histone- (I), and nucleosome- (J–K) reactive serum Ab titers in 6–9 month old, sex matched B6 and B6.Sle1b mice are shown. Each circle represents an individual mouse and B6.Sle1b mice are depicted in black circles while B6 mice are depicted in white circles. Statistical analysis was performed as described in Materials and Methods.