Figure 2.

Structure model of FOXP3 mediated regulatory complex. The overall architecture of the intact FOXP3 associated DNA-protein regulatory complex are constructed by using the crystal structure of FOXP2 forkhead domain complexed with DNA and NFAT (Wu et al., 2006), and the crystal structure of the FOXP3 coiled coil motif reported (Song et al., 2012). To regulate gene transcription, the repressor unit from one FOXP3 molecule cooperates with the DNA binding unit from another FOXP3 molecule.