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. Author manuscript; available in PMC: 2013 Dec 7.
Published in final edited form as: Circ Res. 2012 Sep 10;111(12):1539–1550. doi: 10.1161/CIRCRESAHA.112.279109

Figure 6. Knockdown of endothelial Adam10 and Adam17 differentially affects collateral formation.

Figure 6

A,B, Same tamoxifen protocol as in Figure 4. Reduction in a disintegrin and metalloprotease (ADAM) 10 and 17 prior to collaterogenesis increases (A) and decreases (B) collateral formation. C, Inhibition of γ-secretase with N-[N-(3,5-difluorophenacetyl)-1-alanyl]-S-phenylglycine t-butyl ester (DAPT) enhances collaterogenesis. Constitutive reduction of EC Adam10 (D) or Adam17 (E), beginning at conception, alters collateral number but not diameter (F) in adults.