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. Author manuscript; available in PMC: 2014 Jan 1.
Published in final edited form as: Psychopharmacology (Berl). 2012 Aug 11;225(2):313–327. doi: 10.1007/s00213-012-2820-z

Fig. 6. Fluid drinking affected by CRF-R1 antagonist in DRN.

Fig. 6

Vehicle (v) aCSF, 0.3, and 0.6 μg CP-154,526 were microinjected into the dorsal raphé nucleus (DRN) of mice given intermittent access (a, n=8) or continuous access to alcohol (b, n=8). High ethanol-preferring Long-Evans rats (c, n=7) or low ethanol-preferring rats (d, n=9) were also tested for intra-DRN modulations of fluid drinking. Mean fluid intake in milliliters (ml) over the initial 2 hr access period is displayed ± SEM. Both 20% ethanol (black circles) and water (white circles) intake were measured in the two-bottle choice procedure. * p < .05 compared to vehicle, ** p < .001 compared to vehicle.